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Buy 30 tablets of 20 MG Hydrocone (HYSINGLA ER)

$300.00 $280.00

Brand Name: Zohydro ER, Hysingla ER, Vantrela ER

Generic Name: hydrocodone

Drug Class: Opioid Analgesics


Hydrocodone is a prescription narcotic indicated for the management of pain severe enough to require daily, around-the-clock, long-term treatment and for which alternative treatment options are inadequate.

Hydrocodone is available under the following different brand names: Zohydro ER, Hysingla ER, and Vantrela ER.

Categories: , ,


Dosages of Hydrocodone

Adult dosage only. Safety and efficacy not established for pediatric use.

Capsule, extended release (Zohydro ER): Schedule II

Abuse-deterrent product (BeadTek technology)

  • 10 mg
  • 15 mg
  • 20 mg
  • 30 mg
  • 40 mg
  • 50 mg

Tablet, extended release (Hysingla ER): Schedule II


Dosage Considerations — Should Be Given As Follows:

Chronic Pain

  • Indicated for the management of pain severe enough to require daily, around-the-clock, long-term treatment and for which alternative treatment options are inadequate

Initial dosing

  • Should be prescribed only by healthcare professionals who are knowledgeable inthe use of potent opioids for the management of chronic pain
  • Initiate the dosing regimen for each patient individually, taking into account the patient’s prior analgesic treatment experience and risk factors for addiction, abuse, and misuse
  • Monitor patients closely for respiratory depression, especially within the first 24-72 hours of initiating therapy

Opioid naïve or first opioid analgesic

  • Use of higher starting doses in patients who are not opioid tolerant may cause fatal respiratory depression

Zohydro ER

  • 10 mg orally every 12 hours initially
  • A single dose of Zohydro ER greater than 40 mg, Zohydro ER 50 mg capsules, or a total daily dose greater than 80 mg are only for patients in whom tolerance to an opioid of comparable potency is established

Hysingla ER

  • Administer once daily as 20 mg orally every 24 hours initially
  • Daily doses of Hysingla ER greater than or equal to 80 mg/day are only for use in opioid tolerant patients

Opioid tolerant

See prescribing information for conversion table from existing opioid analgesic to hydrocodone extended-release.

Opioid tolerance definition

Defined as patients who are receiving the following opioids (or an equianalgesic dose of another opioid) for 1 week or longer.

Dose adjustment, maintenance, and discontinuation

  • Zohydro ER: Increase by increments of 10 mg every 12 hours every 3-7 days as needed to achieve adequate analgesia
  • Hysingla ER: Increase by increments of 10-20 mg/day every 3-5 days as needed to achieve adequate analgesia
  • Vantrela ER: May increase to the next higher dose every 3-7 days as needed to achieve adequate analgesia
  • Assess pain frequently for toxicity, breakthrough pain, or need for short-acting rescue analgesia
  • Discontinue by a gradual downward titration every 2-4 days; do not withdraw abruptly

Dosage Modifications

Liver impairment

Mild-to-moderate (Vantrela ER): Initiate therapy with one-half of the recommended initial dose and adjust the dose carefully; use alternative analgesia for patients requiring less than 15 mg. Severe: Initiate with lowest dose, 10 mg (Zohydro ER) or 50% of initial dose (Hysingla ER) and monitor closely for signs of respiratory depression and excessive sedation.

Kidney impairment

Patients with kidney impairment may have higher plasma concentrations than those with normal function. Moderate-to-severe and end stage renal disease: Initiate therapy with a low initial dose (Zohydro ER) or 50% of initial dose (Hysingla ER, Vantrela ER) and monitor closely for respiratory depression and sedation.

Dosing Considerations

Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve use for patients for whom alternative treatment options (for example non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.Not indicated for acute pain or as an as-needed analgesic.


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